Background: Infections due to papillomaviruses condyloma stds are common and lead to a wide variety of clinical manifestations involving the epidermal surfaces , stds , condyloma , genital warts , hpv , herpesManifestations include common warts (verrucae vulgaris) , palmo-plantar warts, flat warts (verrucae plana) , condyloma , oral warts, focal epithelia hyperplasia, epidermodysplasia verruciformis (EDV) , genital warts (condyloma acuminata) , stds , Bowen papulosis, Bowen disease, papillomas of the mucosal surfaces, and intraepithelial neoplasias , stds , condyloma , genital warts , hpv , herpesVery strong evidence indicates that certain papillomaviruses papillomaviruses condyloma are involved in cervical and genital cancers , stds , condyloma , genital warts , hpv , herpes

Pathophysiology: Papillomaviruses are small (55 nm) , double-stranded DNA viruses , stds , condyloma , genital warts , hpv , herpesOver 200 genotypes of papillomaviruses infect the skin and mucosal surfaces , stds , condyloma , genital warts , hpv , herpessurfaces , stds , condyloma , genital warts , hpv , herpesThese viruses stds are highly highly species specific , stds , condyloma , genital warts , hpv , herpesMore than 70 genotypes condyloma are known to infect humans , stds , condyloma , genital warts , hpv , herpesPapillomaviruses have never been cultured in vitro but have been characterized by molecular methods , stds , condyloma , genital warts , hpv , herpesThese viruses are classified by the molecular similarity similarity of their genetic material and condyloma are assigned a genotype genotype number , stds , condyloma , genital warts , hpv , herpesstds

The viruses infect the basal keratinocyte of the epidermis, presumably through disruptions of the skin or mucosal surface , stds , condyloma , genital warts , hpv , herpesAt this location, the condyloma the virus remains latent in the cell as a circular episome , stds , condyloma , genital warts , hpv , herpesAs the epidermal cells differentiate and migrate to the surface, the virus is triggered triggered to undergo replication and maturation , stds , condyloma , genital warts , hpv , herpesstds The process of virus virus replication alters condyloma the character of the epidermis, resulting in cutaneous or mucosal excrescences known as warts , stds , condyloma , genital warts , hpv , herpes

Human papillomaviruses (HPVs) are grouped broadly into cutaneous and mucosal types, based on the clinical location location of condyloma the lesion , stds , condyloma , genital warts , hpv , herpesAlthough Although some overlap exists, most papillomaviruses have distinct anatomic predilections, infecting only certain epidermal sites, such as skin or genital mucosa , stds , condyloma , genital warts , hpv , herpesA number of genotypes of virus have stds the potential potential to transform cells and condyloma are associated with epidermal malignancies , stds , condyloma , genital warts , hpv , herpesThe mechanism for transformation is not known, but viral DNA DNA apparently integrates into stds the genome of the host cell , stds , condyloma , genital warts , hpv , herpes

Table 1 , stds , condyloma , genital warts , hpv , herpesAssociation of of HPV Types with Morphology and Site of Skin Lesions condyloma

Lesion Location HPV Genotype

Common wart Mostly hands 2, 4

Plantar wart Bottom of feet 1

Mosaic wart Hands and feet 2

Flat wart Arms, face, knees 3, 10, 10, 10, 28, 41 condyloma stds

Butcher wart Hand 7

Extragenital Bowen disease Upper and lower extremities, head 2, 3, 5, 16, 18, 20, 31, 33, 34, 54, 56, 58, 61, 62, 73

Macular plaques of epidermodysplasia verruciformis Light-exposed verruciformis Light-exposed areas 5, 8, 9, 12, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 36,