Background: Infections due to papillomaviruses hpv sexually transmitted diseases are common and lead to a wide variety of clinical manifestations involving the epidermal surfaces , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvManifestations include common warts (verrucae vulgaris) , palmo-plantar warts, flat warts (verrucae plana) , hpv , oral warts, focal epithelia hyperplasia, epidermodysplasia verruciformis (EDV) , genital warts (condyloma acuminata) , sexually transmitted diseases , Bowen papulosis, Bowen disease, papillomas of the mucosal surfaces, and intraepithelial neoplasias , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvVery strong evidence indicates that certain papillomaviruses papillomaviruses hpv are involved in cervical and genital cancers , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsv

Pathophysiology: Papillomaviruses are small (55 nm) , double-stranded DNA viruses , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvOver 200 genotypes of papillomaviruses infect the skin and mucosal surfaces , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvsurfaces , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvThese viruses sexually transmitted diseases are highly highly species specific , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvMore than 70 genotypes hpv are known to infect humans , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvPapillomaviruses have never been cultured in vitro but have been characterized by molecular methods , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvThese viruses are classified by the molecular similarity similarity of their genetic material and hpv are assigned a genotype genotype number , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvsexually transmitted diseases

The viruses infect the basal keratinocyte of the epidermis, presumably through disruptions of the skin or mucosal surface , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvAt this location, the hpv the virus remains latent in the cell as a circular episome , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvAs the epidermal cells differentiate and migrate to the surface, the virus is triggered triggered to undergo replication and maturation , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvsexually transmitted diseases The process of virus virus replication alters hpv the character of the epidermis, resulting in cutaneous or mucosal excrescences known as warts , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsv

Human papillomaviruses (HPVs) are grouped broadly into cutaneous and mucosal types, based on the clinical location location of hpv the lesion , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvAlthough Although some overlap exists, most papillomaviruses have distinct anatomic predilections, infecting only certain epidermal sites, such as skin or genital mucosa , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvA number of genotypes of virus have sexually transmitted diseases the potential potential to transform cells and hpv are associated with epidermal malignancies , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvThe mechanism for transformation is not known, but viral DNA DNA apparently integrates into sexually transmitted diseases the genome of the host cell , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsv

Table 1 , sexually transmitted diseases , condyloma , genital warts , herpes , hpv , hsvAssociation of of HPV Types with Morphology and Site of Skin Lesions hpv

Lesion Location HPV Genotype

Common wart Mostly hands 2, 4

Plantar wart Bottom of feet 1

Mosaic wart Hands and feet 2

Flat wart Arms, face, knees 3, 10, 10, 10, 28, 41 hpv sexually transmitted diseases

Butcher wart Hand 7

Extragenital Bowen disease Upper and lower extremities, head 2, 3, 5, 16, 18, 20, 31, 33, 34, 54, 56, 58, 61, 62, 73

Macular plaques of epidermodysplasia verruciformis Light-exposed verruciformis Light-exposed areas 5, 8, 9, 12, 14, 15, 17, 19, 20, 21, 22, 23, 24, 25, 36,