Background: Infections due to papillomaviruses gentile wart genital wart are common and lead to a wide variety of clinical manifestations involving the epidermal surfaces , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertManifestations include common warts (verrucae vulgaris) , palmo-plantar warts, flat warts (verrucae plana) , gentile wart , oral warts, focal epithelia hyperplasia, epidermodysplasia verruciformis (EDV) , genital warts (condyloma (condyloma acuminata) genital wart , Bowen papulosis, Bowen disease, papillomas of the mucosal surfaces, and intraepithelial neoplasias , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertVery strong evidence indicates that certain papillomaviruses papillomaviruses gentile wart are involved in cervical and genital cancers , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wert

Pathophysiology: Papillomaviruses are small (55 nm) , double-stranded DNA viruses , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertOver 200 genotypes of papillomaviruses infect the skin skin and mucosal surfaces , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertThese viruses genital wart are highly highly species specific , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertMore than 70 genotypes gentile wart are known to infect humans , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertPapillomaviruses have never been cultured in vitro but have been characterized by molecular methods , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertThese viruses are classified by the molecular similarity similarity of their genetic material and gentile gentile wart genital wart are assigned a genotype number , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wert

The viruses infect the basal keratinocyte of the epidermis, presumably through disruptions of the skin or mucosal surface , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertAt this location, the gentile wart the virus remains latent in the cell as a circular episome , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertAs the epidermal cells differentiate and migrate to to genital wart the surface, the virus is triggered to undergo replication and maturation , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertThe process of virus virus replication alters gentile wart the character of the epidermis, resulting in cutaneous or mucosal excrescences known as warts , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wert

Human papillomaviruses (HPVs) are grouped broadly into cutaneous and mucosal types, based on the clinical clinical location location of gentile wart genital wart the lesion , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertAlthough some overlap exists, most papillomaviruses have distinct anatomic predilections, infecting only certain epidermal sites, such as skin or genital mucosa , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertA number of genotypes of virus have the potential potential to transform cells and gentile wart are associated with epidermal malignancies , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertThe genital wart The mechanism for transformation is not known, but viral DNA apparently integrates into the genome of the host cell , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wert

Table 1 , genital wart , condyloma , gentile wart , genitle wart , genitla wart , genital wertAssociation of of HPV Types with Morphology and Site of Skin Lesions gentile wart

Lesion Location HPV Genotype

Common wart Mostly hands 2, 4

Plantar wart Bottom of feet 1

Mosaic Mosaic wart Hands and feet 2 genital wart

Flat wart Arms, face, knees 3, 10, 10, 28, 41 gentile wart

Butcher wart Hand 7

Extragenital Bowen disease Upper and lower extremities, head 2, 3, 5, 16, 18, 20, 31, 33, 34, 54, 56, 58, 61, 62, 73

Macular plaques of epidermodysplasia verruciformis Light-exposed verruciformis Light-exposed areas 5, 8, 9, 12,